The aim of the project is to identify Adeno-associated virus (AAV) toxicity biomarkers by cutting edge spatial proteomics tools in vitro.
AAV is a small parvovirus composed of a capsid, which can be engineered to act as a vector delivery system for gene therapy or to enable in vivo expression of biologics. In a minority of cases, application of AAV based therapies lead to adverse effects (AE) in the clinic, including liver toxicity.
You will employ a multi-omics approach to characterize AAV-cell interactions, using novel spatial proteomics methods developed by Professor Kathryn Lilley's group (http://proteomics.bio.cam.ac.uk/), that accurately locate proteins to subcellular structures on a proteome wide scale
Fully-Funded MRC PhD Studentships 2022 is available to undertake PhD level programs at University of Cambridge.
Following subject are available to study under this scholarship program.
A stipend (currently approx.. £17500) will be provided for up to 4 years. This funding covers the University Composition Fee (Home fees rate) and Maintenance and consumables.
The studentship is open to UK citizens or EU students who meet the UK residency requirements for Home fees, and international (including EU) candidates able to provide the difference in Home and Overseas fees from other sources.
To apply please e-mail Prof. Lilley ([email protected]) with following information by 18th March 2022: CV (max two pages), with full contact details of 2 academic referees and a covering letter (max two pages) highlighting (a) your research interests (b) what you hope to achieve from the programme, (c) your career aspirations (d) why you wish to undertake this PhD.
Also, please apply to the University by the above deadline using the Applicant Portal: http://www.graduate.study.cam.ac.uk/how-do-i-apply. Fully completed applications. Please search in the Course Directory for "Biochemistry" PhD studentships. PLEASE NOTE you must complete the 'Research Summary' section of the University application form.