PhD Bioinformatics Scholarship, Belgium at Laboratory of Angiogenesis and Vascular Metabolism
The focus of the Laboratory of Angiogenesis and Vascular Metabolism (VRC, headed by Prof. Peter Carmeliet) is to unravel the molecular mechanisms of angiogenesis (blood vessel formation) in health and disease in order to identify novel therapeutic applications. The lab of Prof. Carmeliet initiated projects that aim to comprehensively characterize the metabolism of endothelial cells (ECs, the cells forming the inner lining of blood vessels) in a multi-omics approach.
We use mass spectrometry based metabolomics and ribonucleic acid (RNA) sequencing to quantify several hundred metabolites and thousands of gene transcripts in (patient- and murinederived) endothelial cells. The candidate will be involved in: i) analyzing high density multiomics data to identify metabolic perturbations using in-house developed software; ii) developing new analysis approaches; iii) supporting biologists in analyzing there own data; iv) performing predictive modeling using genome-scale metabolic models (GEMs) to assess the effects of in silico gene silencing / overexpression; and v) helping biologists to perform GEM modeling.