Moscow Institute of Physics and Technology

What you'll study

This PhD combines practical and theoretical training to develop expertise in genome engineering, bioinformatics and molecular biology. Core research themes include programmable nucleases and base editors (principles and applications), genome-wide functional screens, single-cell genomics, transcriptomics and epigenomics, algorithmic analysis of high-throughput sequencing data, and development of computational tools for variant interpretation and design of editing reagents.

• Laboratory techniques: advanced molecular cloning, CRISPR/Cas systems, delivery methods, PCR and next-generation sequencing workflows, single-cell library preparation and functional assays.
• Computational methods: sequence alignment and variant calling, RNA-seq and single-cell analysis, machine learning for genomics, statistical genetics and population-scale data handling.
• Conceptual modules: genome architecture and regulation, DNA repair pathways, synthetic biology design principles, ethical and safety considerations in genome editing.
• Research training: journal clubs, responsible conduct of research, grant-writing workshops, and presentation skills; supervised project leading to an original doctoral thesis.

Programme structure typically consists of an initial period of taught research methods and rotations to define a thesis project, followed by concentrated independent research under the supervision of faculty in the Genome Engineering Laboratory, regular progress seminars and a public defence of the doctoral dissertation.

Entry requirements

Applicants are normally expected to hold a relevant postgraduate degree (Master’s or equivalent) in molecular biology, genetics, bioinformatics, computational biology, biophysics or a closely related discipline. Strong candidates will demonstrate coursework and practical experience in laboratory molecular techniques or computational genomics, depending on the intended research direction.

• Academic transcript and degree certificate from a recognised institution.
• A concise research proposal or statement of research interests that aligns with the Genome Engineering Laboratory’s areas.
• Evidence of research experience: publications, conference presentations, or a description of previous laboratory or computational projects.
• Two or more academic references addressing research potential and technical readiness.
• Proof of language proficiency where required for non-native speakers (English proficiency is commonly requested for scientific literature and presentations; Russian language ability may be beneficial for local collaborations).
• Shortlisted applicants will usually be interviewed by the laboratory team to assess fit, technical knowledge and research independence.

Career prospects

Graduates of this programme are equipped for careers in academic research (postdoctoral positions and faculty roles), biotechnology and pharmaceutical R&D, clinical and diagnostic laboratories, computational genomics and data science teams, and regulatory or policy roles related to genetic technologies. Skillsets developed — experimental genome editing, high-throughput data analysis, and algorithm development — are also well suited to positions in bioinformatics start-ups, synthetic biology companies, and companies focused on precision medicine.

Alumni commonly move into roles such as research scientist, bioinformatics lead, translational scientist, or technology development specialist; some pursue entrepreneurial routes to commercialise new genome-engineering tools and workflows.

Why study at Moscow Institute of Physics and Technology

MIPT provides a research-intensive environment with a strong emphasis on quantitative training and interdisciplinary approaches, making it well suited for projects that combine wet-lab genome engineering with computational genomics. Students benefit from close interactions with research groups across molecular biology, computer science and physics, access to core facilities for sequencing and imaging, and collaborative links with national research institutes and hospitals in the Moscow scientific ecosystem.

The Genome Engineering Laboratory at MIPT mentors doctoral researchers in hypothesis-driven and method-development projects, supports attendance at international conferences, and fosters a culture of rigorous experimental design and reproducible computational analysis. Prospective students looking for a balance of hands-on molecular work and advanced bioinformatics will find an environment geared toward developing independent, interdisciplinary scientists.